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Allergic Rhinitis & Food Allergy Immunotherapy

Research Area (Focus): Allergic Rhinitis

Allergic rhinitis (AR), commonly known as hay fever, is a chronic inflammation of the nasal cavity caused by inhaling airborne allergens, such as pollen, dust, mold, and weeds. This can trigger sneezing, nasal congestion, itchy nose and irritation of the throat, mouth, and eyes.  In the United States, it affects 40 to 60 million individuals. The prevalence of AR has increased over the last several decades and this trend is expected to continue.

The only disease modifying therapy which currently available to patients is allergen specific immunotherapy (AIT). AIT is a targeted treatment consisting of a small amount of allergen extract given sublingually or subcutaneously over the course of a few years. AIT requires long-term commitment (3 to 5 years), resulting in low patient adherence and high patient costs.

Inimmune’s Pipeline: INI-2004

At Inimmune we’re developing a rapid disease modifying treatment which does not require identification of the allergen. INI-2004 is an allergen agnostic immunotherapy that binds and activates Toll-like receptor 4. When delivered intranasally, INI-2004 dramatically reduced measures of AR in pre-clinical animal models. These include airway resistance, eosinophil influx, and the production of cytokines indicative of an allergic response. Phase I clinical studies will begin in Q2 2023. Demonstration of safety and efficacy in people will lead to a first-in-class, disease-modifying treatment for AR that may be used for any allergen, potentially changing how AR is treated worldwide.  

Inimmune is a promising new biotechnology company founded by pharmaceutical industry veterans, focused on developing the next generation of vaccines and immunotherapeutics.

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  • 1121 E Broadway St, Ste 106, Missoula, MT, 59802
  • 406-541-5913
  • info@inimmune.com

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To combat the opioid epidemic and the growing problem of drug resistant bacteria Inimmune is developing novel vaccines adjuvanted with our proprietary innate immune stimulators.
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At Inimmune, we’re developing a rapid disease modifying treatment which does not require identification of the allergen. INI-2004 is an allergen agnostic immunotherapy that reprograms the allergic immune response, desensitizing the patient against allergens of concern.
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Read More
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TLR-7/8 (INI-4001), TLR-4 (INI-2002), CTLR (UM-1098), STING