An autoimmune disease results from a malfunction in the immune system where healthy cells are mistaken for foreign invaders, causing the immune system to attack these healthy cells.
According to the American Autoimmune Related Diseases Association (AARDA), autoimmune disease affects up to 50 million Americans. Autoimmune diseases include rheumatoid arthritis, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), and type I diabetes among many others. Currently, treatment for autoimmune diseases focuses on relieving symptoms because there is no curative therapy.
The insidious and ongoing threat posed by emerging biological pathogens (Ebola, Chikungunya, MERS CoV, SARS, Influenza, Zika), opportunistic infections (Staphylococcus aureus, pneumococcus, Candidiasis, adenovirus) and bioterrorism agents (B. Anthracis, Y. pestis, B. Pseudomallei, F. tularensis, Bunyaviridae, Flaviviridae) are of significant concern to populations around the globe.
Microorganisms isolated from extreme environments have proven to be a good source for the discovery of novel, bioactive compounds. A co-culture of two extremophilic fungi, Penicillium fuscum and P. camembertii/clavigerum, that were isolated from a single sample of surface water from the Berkeley Pit Lake superfund site yielded a novel antibiotic, Berkeleylactone A (BA), with activity against methicillin resistant S. aureus (MRSA).
TLR-7/8 (INI-4001), TLR-4 (INI-2002), CTLR (UM-1098), STING
Inimmune is advancing a novel TLR7/8 agonist nanoparticle formulation to the clinic to treat cancer by harnessing the patient’s immune system and synergizing with existing immune checkpoint inhibitor therapies. Further, we’re leveraging our expertise in innate immune activation to develop novel compounds and technology to target other immune receptors to develop the next generation of disruptive therapies in oncology.
Professional doctor or nurse giving flu or COVID-19 injection to patient. Woman in medical face mask getting antiviral vaccine at hospital or health center during vaccination and immunization campaign.