{"id":577,"date":"2024-05-30T18:13:10","date_gmt":"2024-05-30T18:13:10","guid":{"rendered":"https:\/\/inimmune.com\/?page_id=577"},"modified":"2024-08-20T17:58:27","modified_gmt":"2024-08-20T17:58:27","slug":"cancer-immunotherapy","status":"publish","type":"page","link":"https:\/\/inimmune.com\/?page_id=577","title":{"rendered":"Cancer Immunotherapy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"577\" class=\"elementor elementor-577\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-691f7d6 e-flex e-con-boxed e-con e-parent\" data-id=\"691f7d6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-667f2ca elementor-widget elementor-widget-heading\" data-id=\"667f2ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Cancer Immunotherapy<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f363c2 elementor-widget elementor-widget-text-editor\" data-id=\"1f363c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>For ongoing clinical trial information: <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06302426\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #435589;\">NCT06302426<\/span><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98493bc elementor-hidden-tablet_extra elementor-hidden-tablet elementor-hidden-mobile_extra elementor-hidden-mobile elementor-widget elementor-widget-video\" data-id=\"98493bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/9o-s29rAawU&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/inimmune.com\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/ss-video-2.jpg&quot;,&quot;id&quot;:582,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;&quot;,&quot;source&quot;:&quot;library&quot;},&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/ss-video-2.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"80\" height=\"80\" viewBox=\"0 0 80 80\" fill=\"none\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M40 80C62.0914 80 80 62.0914 80 40C80 17.9086 62.0914 0 40 0C17.9086 0 0 17.9086 0 40C0 62.0914 17.9086 80 40 80ZM33.75 54.6721L56.25 42.096C57.9167 41.1645 57.9167 38.8355 56.25 37.904L33.75 25.3279C32.0833 24.3963 30 25.5608 30 27.4239L30 52.5761C30 54.4392 32.0833 55.6037 33.75 54.6721Z\" fill=\"white\"><\/path><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6fdc99c elementor-hidden-desktop elementor-hidden-laptop elementor-widget elementor-widget-video\" data-id=\"6fdc99c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/9o-s29rAawU&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/inimmune.com\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/ss-video-2.jpg&quot;,&quot;id&quot;:582,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;&quot;,&quot;source&quot;:&quot;library&quot;},&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/ss-video-2.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"40\" height=\"40\" viewBox=\"0 0 40 40\" fill=\"none\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M20 40C31.0457 40 40 31.0457 40 20C40 8.9543 31.0457 0 20 0C8.9543 0 0 8.9543 0 20C0 31.0457 8.9543 40 20 40ZM16.875 27.3361L28.125 21.048C28.9583 20.5822 28.9583 19.4178 28.125 18.952L16.875 12.6639C16.0417 12.1982 15 12.7804 15 13.7119L15 26.2881C15 27.2196 16.0417 27.8018 16.875 27.3361Z\" fill=\"white\"><\/path><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b32d406 elementor-widget elementor-widget-text-editor\" data-id=\"b32d406\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Every year, cancer claims the lives of more than half a million Americans and is the <a href=\"https:\/\/gis.cdc.gov\/Cancer\/USCS\/#\/AtAGlance\/\" target=\"_blank\" rel=\"noopener\">second leading cause of death in the United States.<\/a> While checkpoint inhibitors and other novel immunotherapies have resulted in increased life expectancy for some people, current immunotherapies still fail in nearly 80% of cancer patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42cb98d elementor-widget elementor-widget-heading\" data-id=\"42cb98d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">INI-4001 Cancer Immunotherapy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29a5b7b elementor-widget elementor-widget-text-editor\" data-id=\"29a5b7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>At Inimmune, we are using our expertise in innate immunity to produce new therapeutics to treat cancer. Our current clinical-stage cancer therapeutic is INI-4001, a potent TLR7\/8 agonist that has been optimized for nanoparticle delivery. INI-4001 demonstrates efficacy as monotherapy and in combination with immune checkpoint therapy (ICT), such as anti-PD-1, in multiple pre-clinical murine cancer models. Our optimized nanoparticle formulation for INI-4001 enhances anti-tumor efficacy, maintaining high IFN\u03b1 production while reducing pro-inflammatory TNF\u03b1. Mechanistically, INI-4001 increases the number of APCs and enhances CD8 T cell responses in the tumor microenvironment. We enrolled our first patient in our Phase I clinical trial using INI-4001 in solid tumor cancer indications started in July 2024. This is an open-label, all solid tumor trial investigating the safety of INI-4001 alone and in combination with various checkpoint inhibitors that will also result in preliminary efficacy data. To learn more about our ongoing clinical trial, please visit <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06302426\" target=\"_blank\" rel=\"noopener\">www.clinicaltrials.gov.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-652c987 elementor-align-left cstom-icon-hover elementor-widget elementor-widget-button\" data-id=\"652c987\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/wp-content\/uploads\/2024\/06\/Cancer_221108-SITC-Poster.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">View Poster<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f4cfa8 elementor-widget elementor-widget-heading\" data-id=\"2f4cfa8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Next Generation Immunotherapies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a47b374 elementor-widget elementor-widget-text-editor\" data-id=\"a47b374\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In our pre-clinical pipeline, we are exploring novel compounds targeting other innate immune receptors, such as STING and CLRs, as well as advanced delivery systems to target immunotherapy directly to the tumor and tumor microenvironment.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cancer Immunotherapy For ongoing clinical trial information: NCT06302426 https:\/\/youtu.be\/9o-s29rAawUhttps:\/\/youtu.be\/9o-s29rAawU Every year, cancer claims the lives of more than half a million Americans and is the second leading cause of death in the United States. While checkpoint inhibitors and other novel immunotherapies have resulted in increased life expectancy for some people, current immunotherapies still fail in [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-577","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Cancer Immunotherapy For ongoing clinical trial information: NCT06302426 Every year, cancer claims the lives of more than half a million Americans and is the second leading cause of death in the United States. 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