{"id":618,"date":"2024-05-30T19:08:37","date_gmt":"2024-05-30T19:08:37","guid":{"rendered":"https:\/\/inimmune.com\/?page_id=618"},"modified":"2024-06-17T13:55:34","modified_gmt":"2024-06-17T13:55:34","slug":"ini-1098-vaccine-adjuvant","status":"publish","type":"page","link":"https:\/\/inimmune.com\/?page_id=618","title":{"rendered":"INI-1098 Vaccine Adjuvant"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"618\" class=\"elementor elementor-618\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6586e6 e-flex e-con-boxed e-con e-parent\" data-id=\"a6586e6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d77b46e elementor-widget elementor-widget-heading\" data-id=\"d77b46e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">INI-1098 Vaccine Adjuvant<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb1b571 elementor-widget elementor-widget-text-editor\" data-id=\"fb1b571\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A novel synthetic Mincle agonist<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d30784 elementor-widget elementor-widget-image\" data-id=\"0d30784\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/chemistry-lab-1024x683.jpg\" class=\"attachment-large size-large wp-image-620\" alt=\"\" srcset=\"https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/chemistry-lab-1024x683.jpg 1024w, https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/chemistry-lab-300x200.jpg 300w, https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/chemistry-lab-768x512.jpg 768w, https:\/\/inimmune.com\/wp-content\/uploads\/2024\/05\/chemistry-lab.jpg 1320w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17f6b3c elementor-widget elementor-widget-text-editor\" data-id=\"17f6b3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>INI-1098 is a novel synthetic Mincle agonist that is being developed as a Th17-generating adjuvant for bacterial and fungal pathogens. Mincle is a C-type lectin receptor (CLR) that was originally discovered as the ligand for the Mycobacterium tuberculosis (Mtb) cell wall component trehalose dimycolate (TDM). Th17 cells play a key role in the immune system\u2019s defenses against certain bacterial and fungal pathogens, including Mtb. There are currently not any Th17-inducing vaccines in clinical use. We aim to be the first with INI-1098.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be3eb14 elementor-widget elementor-widget-heading\" data-id=\"be3eb14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Upcoming Manufacturing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6a9403 elementor-widget elementor-widget-text-editor\" data-id=\"b6a9403\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In pre-clinical mouse models of TB vaccination and challenge, INI-1098 adjuvanted TB vaccination results in a Th17 and Th1 polarization of the T cell response and protects against TB challenge. Vaccine studies in larger animal models also resulted in Th17 polarized adjuvant mediated immune responses. INI-1098 will be manufactured cGMP via an NIH funded Adjuvant Development Contract.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>INI-1098 Vaccine Adjuvant A novel synthetic Mincle agonist INI-1098 is a novel synthetic Mincle agonist that is being developed as a Th17-generating adjuvant for bacterial and fungal pathogens. Mincle is a C-type lectin receptor (CLR) that was originally discovered as the ligand for the Mycobacterium tuberculosis (Mtb) cell wall component trehalose dimycolate (TDM). Th17 cells [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-618","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"INI-1098 Vaccine Adjuvant A novel synthetic Mincle agonist INI-1098 is a novel synthetic Mincle agonist that is being developed as a Th17-generating adjuvant for bacterial and fungal pathogens. Mincle is a C-type lectin receptor (CLR) that was originally discovered as the ligand for the Mycobacterium tuberculosis (Mtb) cell wall component trehalose dimycolate (TDM). 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