Infections caused by multidrug-resistant (MDR) bacteria such as Pseudomonas aeruginosa (Pa) are a growing threat to human life. The World Health Organization (WHO) recently categorized Pa as a priority pathogen of the greatest risk to human health. PA opportunistically infects diabetic wounds, cystic fibrosis airways, and medical materials (such as ventilators, bandages, and catheters), resulting in hospital acquired infections. Each year, fewer viable options are available to treat Pa infections due to drug resistance. No effective vaccine is available to prevent infection. A major hurdle to developing an effective Pa vaccine is identifying well conserved molecular targets from the wide range of Pa strains that infect humans which are amenable to immunization.
Breakthrough research led by Dr. Pat Secor at the University of Montana and colleagues have found that approximately 84% of Pa isolates are infected by a filamentous bacteriophage (a virus that infects bacteria) called Pf. Vaccinating against the major coat protein (CoaB) of Pf virions prevents Pa from establishing an infection in a mouse wound model (Sweere, Science 2019). Using our proprietary vaccine adjuvant INI-2002, we, in collaboration with Dr. Secor, have developed a series of conjugate vaccines that target the well-conserved CoaB antigen found on the strains of Pf phage that infect diverse Pa isolates, including drug resistant strains.
Sweere JM, Van Belleghem JD, Ishak H, et al. Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. Science 2019;363
TLR-7/8 (INI-4001), TLR-4 (INI-2002), CTLR (UM-1098), STING
Inimmune is advancing a novel TLR7/8 agonist nanoparticle formulation to the clinic to treat cancer by harnessing the patient’s immune system and synergizing with existing immune checkpoint inhibitor therapies. Further, we’re leveraging our expertise in innate immune activation to develop novel compounds and technology to target other immune receptors to develop the next generation of disruptive therapies in oncology.
Professional doctor or nurse giving flu or COVID-19 injection to patient. Woman in medical face mask getting antiviral vaccine at hospital or health center during vaccination and immunization campaign.