Upper respiratory tract infections (URTI) are acute infections involving the swelling of the upper airways with associated cough, nasal obstruction, sore throat, headaches, muscle aches and fever. URTIs can be caused by both viruses and bacteria. Seasonal, endemic, and new respiratory infections are a continuous threat to our health and safety.
At Inimmune we’re advancing a revolutionary approach with the use of immunomodulators capable of eliciting a robust innate immune response that provides protective resistance against a wide range of biological pathogens. Inimmune is developing a safe, self-administered intranasal prophylactic to reduce the severity of URTIs in individuals or populations at risk for infections with emerging or opportunistic pathogens.
INI-2004 is a synthetic Toll-Like Receptor (TLR) 4 agonist that triggers the host innate immune response to provides protection against invading pathogens, including the influenza virus, within hours of intranasal administration. In pre-clinical models, this protection lasts for at least 28 days after a single intranasal administration. Additionally, nanoparticle formulations of INI-2004 provide an improved tolerability profile and provide an excellent delivery vehicle for mucosal routes of administration.
INI-2004 has the potential to help reduce morbidity and mortality in humans at risk of infection with respiratory pathogens of significant medical concern. INI-2004 can provide rapid protection against new and emerging pathogens, including those with pandemic potential, while vaccines are under development.
TLR-7/8 (INI-4001), TLR-4 (INI-2002), CTLR (UM-1098), STING
Inimmune is advancing a novel TLR7/8 agonist nanoparticle formulation to the clinic to treat cancer by harnessing the patient’s immune system and synergizing with existing immune checkpoint inhibitor therapies. Further, we’re leveraging our expertise in innate immune activation to develop novel compounds and technology to target other immune receptors to develop the next generation of disruptive therapies in oncology.
Professional doctor or nurse giving flu or COVID-19 injection to patient. Woman in medical face mask getting antiviral vaccine at hospital or health center during vaccination and immunization campaign.